QTMeds

Drug Database Monograph

CRONOMIR 10 microgrammes/mL solution injectable/pour perfusion

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Active Ingredient: NORADRENALINE

QTc Interval Status:
neutre

Clinical Description (Database Summary)

(Hérité de TANOREN 0) Norepinephrine does not acutely alter cardiac conduction or repolarization parameters. In a prospective observational study of 135 emergency department patients (median age 77 years), short-term therapeutic-dose IV infusion over 2 hours produced no statistically significant changes in heart rate, PR interval, QRS duration, QT/QTcB intervals, or frontal QRS-T angle (a marker of ventricular repolarization heterogeneity, p = 0.273). Similar safety profiles were confirmed in sepsis subgroups, indicating a safe electrical profile during acute short-term administration.

Scientific Sources / References

https://doi.org/10.1016/j.hrtlng.2026.102742

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