QTMeds

DIARETYL 2 mg

Clinical Description (Database Summary)

(Hérité de DIASTROLIB 2 mg) Conflicting data : according to this ranzomized clinical study https://doi.org/10.1016/j.japhar.2024.100006, in healthy subjetcs : a single-dose loperamide at therapeutic (8 mg) and supratherapeutic (48 mg) didn't show evidence of QTc prolongation. However : at high doses (70–1600 mg/day) it's highly cardiotoxic. Loperamide exerts a dual electrophysiological threat: - Potent hERG blockade (IKr​): Leading to marked QTc prolongation and Torsades de Pointes (TdP). - Sodium channel inhibition (Nav​1.5): Causing QRS widening and Brugada-like patterns. - Sudden cardiac death and malignant arrhythmias have been widely documented in the context of abuse.

Scientific Sources / References

https://doi.org/10.1111/jce.14129, https://doi.org/10.1016/j.japhar.2024.100006, https://doi.org/10.1016/j.hrcr.2019.01.004