QTMeds

Drug Database Monograph

EXACOR 130 mg

✓ VERIFIED BY DOCTOR

Active Ingredient: CIBENZOLINE

QTc Interval Status:
inconnu

Clinical Description (Database Summary)

Cibenzoline is a class Ia/Ic antiarrhythmic agent that demonstrates a variable effect on the QTc interval across clinical trials. In electrophysiologic studies with intravenous administration, cibenzoline prolonged QTc by an average of 7 percent, alongside a 26 percent increase in QRS duration and a 13 percent prolongation of the PR interval. However, other clinical studies have demonstrated no significant change in QTc duration.

Scientific Sources / References

https://doi.org/10.1016/0002-8703(85)90646-5, https://www.ovid.com/jnls/cardiovascularpharm/abstract/00005344-199003000-00018~effects-of-intravenous-cibenzoline-on-ventricular?redirectionsource=fulltextview, https://doi.org/10.1093/oxfordjournals.eurheartj.a061620

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